EDUCATION
University of Windsor
Department Chemistry & Biochemistry, Windsor, ON, Canada
Research Supervisor: Dr. John. F. Trant
Research Focus: computational chemistry for determining peptide function employing unnatural amino acids
2019 -
Postdoctoral Fellow
Ardabil University
Faculty of Chemistry, Ardebil, Iran.
Research Supervisor: Dr. Banaei
2003 - 2007
Bachelor's Degree
University of Tabriz
Faculty of Chemistry, Tabriz, Iran.
Research Supervisor: Prof. A. A. Khandar
Research Focus: Synthesis and characterization of Schiff-base ligands with ONO and N2O5 donor based on salicylaldehyde and azophenylsalicylaldehyde and their complexes with some of transition metals
Shahid Beheshti University
Chemistry and Petroleum Sciences Faculty, Tehran, Iran.
Research Supervisor: Prof. N. Safari
Research Focus: Theoretical Calculation and prediction for Experimental Design to Obtain Spin Crossover Complexes
2012 - 2016
Ph.D. Degree
2008 - 2011
Master's Degree
CURRENT PROJECTS
2- Computational Study of Novel Dual-Targeting Probe for Prostate Cancer Molecular Imaging
Prostate specific membrane antigen (PSMA) is a transmembrane protein often overexpressed in prostate cancer (PC). SPSMA cleaves vitamin B9 to stimulate PI3K-Akt signaling through metabotropic glutamate receptors (mGluR). We computational study to design and synthesize novel Cy3-congugated diagnostic glutamate-urea-based probes (GUL-Cy3) for detecting PC with the dual-targeting to both PSMA and mGluRs.
4- Rational Design of Altered Peptide Ligands for Treatment of Autoimmune Disorders
Celiac disease (CD) is an MHC type II autoimmune disorder affecting approximately 1% of western populations and is caused by gluten ingestion which leads to intestinal damage.1 Currently there is no cure. We propose the targeting of human leukocyte antigen (HLA) DQ2 receptors through the use of altered peptide ligands (APLs), which have been rationally designed and are able to competitively inhibit gluten binding and presentation to T cells, especially when combined with other approaches such as cyclization.
3- Computationally analyzing the interactions between the minor cannabinoids and their biological targets
There are 117 minor and understudied cannabinoids may prove even more potent. we attempted to computation study and investigation of the interactions of major, minor and endo- cannabinoids with CB1 and CB2, Serotonin 5-HTIA, Capsaicin, PPAR-Y, GABA-A and Fatty-Acid Binding Proteins with an emphasis on the published crystal structures of the these receptors. In-silico screening will explores the analysis of cannabinoid interactions with mentioned receptors in order to highlight key interactions which may provide clues to better understand the pharmacological effects of cannabis constituents on these receptors.
5- Study of Pholymorphysm in Spin Cross Over (SCO) Compounds
spin-crossover (SCO) materials are particularly attractive for potential applications in molecular sensing, switching, data storage, display, and other electronic devices at nanometric scale. Polymorphism is widely encountered in the studies of crystallization, phase transition, materials synthesis, biomineralization, and in the manufacture of drugs. Studying polymorphism of SCO compounds is therefore important for better understanding the structural factors contributing to spin transition and the structure–function relationship.
1- Repurposing and computationally and structurally some candidate drugs including integrase inhibitors with potential anti-SARS-CoV-2 potential.
Cotinga has a number of HIV integrase inhibitors in preclinical development and we will be using these same techniques to screen them against these proteins. Very preliminary computational results from our lab are predicting that these are far more potent inhibitors of the main protease than the commercial integrase inhibitors (based on induced docking scores and MM-PBSA energy analyses of molecular dynamics simulations).
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Fred Shahbazi, V. Grandi, A. Banerjee, John F. Trant, Cannabinoids and Cannabinoid Receptors: The Story So Far, iscience, 2020.
https://doi.org/10.1016/j.isci.2020.101301
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F. Shahbazi-Raz, J. J. Hayward, D. Meister, M. K. Bakht, L. A. Porter, J. F. Trant, Computational Study and Synthesis of a Novel Dual-Targeting Probe for Prostate Cancer Molecular Imaging, 47th Physical Organic Minisymposium (POMS), 2019.
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F. Shahbazi-Raz, B. Notash, V. Amani. N. Safari,” 4,4′-Dimethyl-2,2′-bithiazole: Potent co-former in coordination compounds,” Polyhedron, Volume 119, 24 November 2016, Pages 227-237.
https://doi.org/10.1016/j.poly.2016.08.017
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F. Shahbazi‐Raz, M. Adineh, N. Safari, M. Zahedi,” Theoretical calculation and prediction for experimental design to obtain spin-crossover complexes,” International Journal of Quantum Chemistry, Volume116, Issue15, August 5, 2016, Pages 1179- 1186.
https://doi.org/10.1002/qua.25154
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F. Shahbazi-Raz, V. Amani, E. B. Noruzi, N. Safari, R, Boča, J. Titiš, B. Notash,” Synthesis, characterization, the electrochemical and magnetic study of mixed ligand mono iron and O-methoxy bridged diiron complexes,” Inorganica Chimica Acta, Volume 435, 24 August 2015, Pages 262-273.
https://doi.org/10.1016/j.ica.2015.07.003
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A. A. Khandar. F. Shahbazi Raz, 12th symposium Inorganic chemistry Seminar Iran, 2010, P-365. A.
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A. Khandar. F. Shahbazi Raz, 13th symposium Inorganic chemistry Seminar Iran, 2010, P-365.
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A. A. khandar(a), Z. Travincek, S. A. Hosseini-Yazdi, F. Shahbazi Raz, The 18th, symposium of society of crystallography and mineralogy of iran,2011.
PUBLICATIONS &
PRESENTATIONS
TEACHING
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Instructor of Inorganic Chemistry Laboratory 1 and 2 Class for undergraduate students, Shahid Beheshti University, 2013-2015, for Three years.
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Instructor of Chemistry at Iran Atomic Energy High School for the students who participated in the International Chemistry Olympiad, 2013, one year.
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Tutor in Chemistry in the Sama High School, Amirabad, Tehran-Iran, 2010, one year.
PROFESSIONAL ACTIVITIES
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Lecturer of Eight-Hour Workshop Entitled: Mass Spectroscopy for Technical assistant of the factories of Golestan, Iran, 2013.
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Member of the Canadian Society for Chemistry (CSC)
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Member of of Iranian Chemistry Society (ICS)
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Member of Iranian Nanotechnology & Nanoscience Society (INIC)
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Managing Editor of “Payame chemisty Annual magazines” at Ardabil university